Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.7
USERS' SCORE
Good
Based on 56 Reviews
8
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Vitamin E (as D-alpha tocopheryl succinate)
20.1 mg
134%
Selenium (as Se-Methyl L-Selenocysteine, L-selenomethionine (yeast-free), sodium selenite)
200 mcg
364%
Top Medical Research Studies
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
Read More
8
We explored the use of selenium-loaded porous silica nanospheres (Se@PSN) as a promising treatment for myocardial infarction (MI). This innovative approach targets harmful reactive oxygen species (ROS), which damage heart cells. By improving antioxidant activity and supporting mitochondrial function, Se@PSN help reduce heart tissue damage and maintain cardiac function after a heart attack. The findings suggest that Se@PSN could be a significant advancement for MI treatments and may offer hope in the clinical realm.
Read More
8
We examined data from over 39,000 people in the NHANES study to see how dietary vitamin E affects heart disease and mortality rates.
The results showed that those consuming more vitamin E had a significantly lower risk of developing cardiovascular disease and lower all-cause mortality rates.
Specifically, participants with higher vitamin E intake experienced a notable decrease in cardiovascular issues, which suggests that a diet rich in vitamin E could be beneficial for heart health and longevity.
The results showed that those consuming more vitamin E had a significantly lower risk of developing cardiovascular disease and lower all-cause mortality rates.
Specifically, participants with higher vitamin E intake experienced a notable decrease in cardiovascular issues, which suggests that a diet rich in vitamin E could be beneficial for heart health and longevity.
Read More
Most Useful Reviews
7.5
Improved heart function
210 people found this helpful
The finest selenium product! As part of the Super Selenium range, it contains three forms of selenium alongside vitamin E. Selenium aids in the normal function of the thyroid gland and boosts immunity. It also enhances the functioning of the heart and brain.
Read More
9
Supports heart health
182 people found this helpful
Wonderful Selenium Vitamin E Complex. Super Selenium Complex consists of three forms of selenium and vitamin E, promoting good health and longevity. It supports normal thyroid and immune function, while improving heart, brain, and healthy cell division. The quality is excellent and the composition is splendid.
Read More
9
Restores energy
27 people found this helpful
Excellent! After experiencing gland deficiency symptoms, I took it alongside Icelandic sea moss, and the results were immediate—I regained energy and started losing weight. The quality is superb and odourless, bringing me joy.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.7
- All Researches
9.5
We looked into how dietary selenium and zinc affect the risk of dilated cardiomyopathy (DCMP) in children. In this case-control study, 36 patients with DCMP were compared to 72 healthy children, assessing their dietary intakes using a food frequency questionnaire.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Our findings revealed that sufficient intake of selenium and zinc significantly lowered the risk of DCMP, suggesting that these nutrients play a protective role. Addressing nutritional deficiencies could improve heart health in affected children, although more research is needed to explore the underlying mechanisms.
Read More
9
Selenium nanoparticles support heart health
We explored how selenium nanoparticles (SeNPs) could help reduce damage from heart attacks, specifically ischemia/reperfusion injury (I/RI). Using a method to create these nanoparticles, we found they possess remarkable properties that combat oxidative stress and inflammation.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
SeNPs seem to disrupt harmful cellular cycles, thereby protecting heart cells. Notably, they improved heart function and reduced cell death and scar tissue in tests. Overall, these findings suggest that SeNPs could be a valuable approach in managing heart conditions after a heart attack.
Read More
9
We explored how a high selenium diet impacts heart health, especially under stress conditions like systolic overload. Using male mice, we compared those on a high selenium diet with those on a normal diet.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
While high selenium didn’t change heart function under normal conditions, it significantly protected against heart issues caused by overload, reducing inflammation and heart muscle growth.
This suggests that a high selenium diet can be beneficial in combating certain heart problems, providing a proactive step for heart health.
Read More
9
Selenium compound shows heart protection
We investigated the effects of a new selenium-containing compound, Se-SAHA, on heart failure caused by isoproterenol. Our study found that Se-SAHA helped protect heart cells from damage, reducing cardiac hypertrophy and fibrosis in lab models.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
It effectively lowered harmful reactive oxygen species and increased vital antioxidative enzymes. Additionally, Se-SAHA hindered the buildup of autophagosomes and reversed certain harmful protein expressions linked to heart stress. Overall, these findings suggest that Se-SAHA could play a protective role in heart health by reducing oxidative stress and altering autophagic processes.
Read More
9
We investigated the use of a new selenium delivery system to combat radiation-induced heart disease, which is a serious concern for cancer patients undergoing thoracic radiation. Our innovative oral microcarriers showed remarkable effects in protecting heart cells from radiation damage by reducing harmful reactive oxygen species.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
Not only did this method improve heart function and reduce signs of damage, but it also supported the immune system by increasing beneficial immune cells after radiation exposure. These promising results suggest that selenium could play a key role in helping to manage and prevent heart complications from radiation therapy.
Read More
User Reviews
USERS' SCORE
Good
Based on 56 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Improved heart function
210 people found this helpful
The finest selenium product! As part of the Super Selenium range, it contains three forms of selenium alongside vitamin E. Selenium aids in the normal function of the thyroid gland and boosts immunity. It also enhances the functioning of the heart and brain.
Read More
9
Supports heart health
182 people found this helpful
Wonderful Selenium Vitamin E Complex. Super Selenium Complex consists of three forms of selenium and vitamin E, promoting good health and longevity. It supports normal thyroid and immune function, while improving heart, brain, and healthy cell division. The quality is excellent and the composition is splendid.
Read More
9
Restores energy
27 people found this helpful
Excellent! After experiencing gland deficiency symptoms, I took it alongside Icelandic sea moss, and the results were immediate—I regained energy and started losing weight. The quality is superb and odourless, bringing me joy.
Read More
8.5
Fights oxidative damage
22 people found this helpful
🌟 Selenium is vital for our health. It combats oxidative damage, maintains a healthy thyroid and immune system, and enhances heart health. Most individuals are deficient in selenium, which is crucial for bodily functions. I take one capsule daily with breakfast or lunch, as it's best consumed in the morning. The capsules are small and the dosage sufficient to remedy the deficiency. I hope my review assists you in making a healthy choice!
Read More
9
Enhanced energy levels
20 people found this helpful
Good❤️🔥❤️ Selenium is a vital trace element; it aids in the absorption of iron and iodine, provides cellular immunity, participates in fat metabolism, and reduces heart attack risk and blood pressure. It helps produce the Q-10 enzyme and improves reproductive functions. This composition includes vitamin E, enhancing selenium absorption and rejuvenating the body. I complete a course and take breaks as needed. My energy has surged, and I feel revitalised and lighter.
Read More
Frequently Asked Questions
9
Enhanced energy levels
4 people found this helpful
The complex is indeed effective! Recommended by my nutritionist to restore thyroid function due to hypothyroidism, I experienced symptoms like fatigue and hair loss. Almost immediately, I began to feel much better, gained energy, and noticed a reduction in hair loss along with improved heart function. I highly recommend it; it’s essential for optimal body performance.
9
Atrial fibrillation support
3 people found this helpful
I take this for my heart. With atrial fibrillation, I supplement with magnesium and selenium. After starting these, I have not experienced any episodes of arrhythmia, which was common when I was on cardiologist's medications.
7.5
Reduced heart attacks
29 people found this helpful
Selenium is a crucial trace element that aids iron and iodine absorption, boosts cellular immunity, and participates in fat metabolism. It reduces the risk of heart attacks and lowers blood pressure. The inclusion of vitamin E enhances selenium absorption and rejuvenates the body. I follow a course of this supplement, and I feel more energetic and alive. Just take one capsule in the morning before meals!
9
Restores energy
27 people found this helpful
Excellent! After experiencing gland deficiency symptoms, I took it alongside Icelandic sea moss, and the results were immediate—I regained energy and started losing weight. The quality is superb and odourless, bringing me joy.
7.5
Reduces inflammation
7 people found this helpful
Selenium with vitamin E! I trust this brand; the complex contains three forms of selenium plus vitamin E for better absorption. With a daily prophylactic dosage, I take one capsule a day. It is a key antioxidant that reduces inflammation, supports heart and blood vessel function, and aids metabolism. Great price to quality ratio!
8.5
Fights oxidative damage
22 people found this helpful
🌟 Selenium is vital for our health. It combats oxidative damage, maintains a healthy thyroid and immune system, and enhances heart health. Most individuals are deficient in selenium, which is crucial for bodily functions. I take one capsule daily with breakfast or lunch, as it's best consumed in the morning. The capsules are small and the dosage sufficient to remedy the deficiency. I hope my review assists you in making a healthy choice!
7.5
Promotes longevity
8 people found this helpful
Best Selenium Complex! I take selenium as a preventative measure. It’s considered a microelement of longevity due to its unique properties. Selenium is crucial for antioxidant defence, immune support, detoxification, and heart health. This supplement is a permanent addition to my routine.
8
We examined the potential of selenium-quantum-dot-loaded silica nanoparticles (Se@PSN) to treat myocardial ischemia-reperfusion (IR) injury, which is often exacerbated by ferroptosis and mitochondrial dysfunction.
Our study demonstrated that Se@PSN significantly improved mitochondrial function and reduced oxidative stress in cardiac cells. These nanoparticles effectively lowered ferroptosis levels and showed great biocompatibility.
Overall, while Se@PSN showed promise in treating myocardial IR injury, further research is needed to solidify its clinical applications.
Our study demonstrated that Se@PSN significantly improved mitochondrial function and reduced oxidative stress in cardiac cells. These nanoparticles effectively lowered ferroptosis levels and showed great biocompatibility.
Overall, while Se@PSN showed promise in treating myocardial IR injury, further research is needed to solidify its clinical applications.
8
We explored the use of selenium-loaded porous silica nanospheres (Se@PSN) as a promising treatment for myocardial infarction (MI). This innovative approach targets harmful reactive oxygen species (ROS), which damage heart cells. By improving antioxidant activity and supporting mitochondrial function, Se@PSN help reduce heart tissue damage and maintain cardiac function after a heart attack. The findings suggest that Se@PSN could be a significant advancement for MI treatments and may offer hope in the clinical realm.
7
We examined how different metals in the blood relate to heart issues in individuals with coronary artery disease (CAD). Our cross-sectional study included 1,555 CAD patients in Southwest China, where we measured the blood concentrations of 14 metals.
Interestingly, we found that lower levels of certain metals, particularly copper and manganese, were linked to poorer cardiac structure and function. On a positive note, higher levels of selenium showed beneficial effects. This suggests that adding selenium or tin might counteract the negative impacts of harmful metals on heart health.
Interestingly, we found that lower levels of certain metals, particularly copper and manganese, were linked to poorer cardiac structure and function. On a positive note, higher levels of selenium showed beneficial effects. This suggests that adding selenium or tin might counteract the negative impacts of harmful metals on heart health.
7
In exploring the connection between vitamins and coronary heart disease (CHD), we analyzed data from a substantial study involving over 33,000 participants from the National Health and Nutrition Examination Survey, covering years 2003-2020.
Our findings revealed that Vitamins E and B6 are associated with a lower risk of CHD, especially among women, individuals with a BMI of 25-30, and smokers. Interestingly, Vitamin B12 showed little impact on heart health.
Overall, our study suggests that increasing Vitamin E and B6 intake might offer protective benefits against heart disease, emphasizing their potential importance in dietary guidelines.
Our findings revealed that Vitamins E and B6 are associated with a lower risk of CHD, especially among women, individuals with a BMI of 25-30, and smokers. Interestingly, Vitamin B12 showed little impact on heart health.
Overall, our study suggests that increasing Vitamin E and B6 intake might offer protective benefits against heart disease, emphasizing their potential importance in dietary guidelines.
References
- Li T, Liu X, Yang B, Wang Z, Chen Y, et al. Selenium-loaded porous silica nanospheres improve cardiac repair after myocardial infarction by enhancing antioxidant activity and mitophagy. Free Radic Biol Med. 2025;232:292. doi:10.1016/j.freeradbiomed.2025.03.004
- He X, Sun H, Zhao Y, Fu X, Wang M, et al. Association of environmental metallic and metalloid contaminants with cardiovascular and all-cause mortality: An umbrella review of systematic reviews and meta-analyses. Eur J Prev Cardiol. 2025. doi:10.1093/eurjpc/zwaf118
- Li T, Yang B, Liu X, Shi D, Wang Z, et al. Silica Nanoparticles Loaded With Selenium Quantum Dots Reduce Myocardial Ischemia-Reperfusion Injury by Alleviating Ferroptosis and Mitochondrial Dysfunction. Int J Nanomedicine. 2025;20:1843. doi:10.2147/IJN.S500810
- Chen C, Ma J, Duan S, Xue M, Yang Z, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: Suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. doi:10.1016/j.biomaterials.2025.123119
- Chen Q, Wang WY, Xu QY, Dai YF, Zhu XY, et al. The enhancing effects of selenomethionine on harmine in attenuating pathological cardiac hypertrophy via glycolysis metabolism. J Cell Mol Med. 2024;28:e70124. doi:10.1111/jcmm.70124
- Heuer RM, Falagan-Lotsch P, Okutsu J, Deperalto M, Koop RR, et al. Therapeutic Efficacy of Selenium Pre-treatment in Mitigating Cadmium-Induced Cardiotoxicity in Zebrafish (Danio rerio). Cardiovasc Toxicol. 2024;24:1287. doi:10.1007/s12012-024-09910-0
- Bhattarai U, Xu R, He X, Pan L, Niu Z, et al. High selenium diet attenuates pressure overload-induced cardiopulmonary oxidative stress, inflammation, and heart failure. Redox Biol. 2024;76:103325. doi:10.1016/j.redox.2024.103325
- Sun Y, Mao Q, Zhou D, Tian J, Du H, et al. Associations of multiple blood metals with cardiac structure and function: A cross-sectional study in a CAD population. Environ Pollut. 2024;360:124718. doi:10.1016/j.envpol.2024.124718
- Marhamati S, Younesian O, Mir SM, Hosseinzadeh S, Joshaghani HR, et al. The effects of high doses of selenium supplementation on mRNA and protein levels of cMLCK levels and total antioxidant capacity in rat heart tissue. Food Chem Toxicol. 2024;191:114886. doi:10.1016/j.fct.2024.114886
- Masle AM, Kibel A, Jukić I, Čičak P, Selthofer-Relatić K, et al. Enhancing Endothelial Function with Nutrient-Enriched Table Hen Eggs: A Randomized Study in Patients Recovering from Acute Coronary Syndrome. Clin Interv Aging. 2024;19:953. doi:10.2147/CIA.S461821
- Cheng T, Liu C, Wang Y, Li G, Feng L, et al. A novel histone deacetylase inhibitor Se-SAHA attenuates isoproterenol-induced heart failure via antioxidative stress and autophagy inhibition. Toxicol Appl Pharmacol. 2024;487:116957. doi:10.1016/j.taap.2024.116957
- Liu C, Wang W, Lai H, Chen Y, Li L, et al. Biosynthesis of fungus-based oral selenium microcarriers for radioprotection and immuno-homeostasis shaping against radiation-induced heart disease. Bioact Mater. 2024;37:393. doi:10.1016/j.bioactmat.2024.03.034
- Aryafar M, Mahdavi M, Shahzadi H, Ranjbar YR, Sohouli MH, et al. Association between dietary selenium and zinc intake and risk of dilated cardiomyopathy in children: a case-control study. BMC Pediatr. 2024;24:251. doi:10.1186/s12887-024-04706-1
- Karaye KM, Sa'idu H, Ishaq NA, Balarabe SA, Ahmed BG, et al. Selenium Deficiency as a Risk Factor for Peripartum Cardiomyopathy. West Afr J Med. 2024;41:209.
- Li SJ, Wang AW, Huang KL, Yang Y. Recent Advances on Selenium Nutrition and Keshan Disease. Int Heart J. 2024;65:173. doi:10.1536/ihj.23-628
- Al-Mubarak AA, Markousis Mavrogenis G, Guo X, De Bruyn M, Nath M, et al. Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes. Redox Biol. 2024;70:103046. doi:10.1016/j.redox.2024.103046
- Zeng Q, Liao M, Li Y, She F, Zhang P. Association between dietary vitamin E intake and incident cardiovascular disease, cardiovascular, and all-cause mortality: A prospective cohort study using NHANES 2003-2018 data. Int J Cardiol Cardiovasc Risk Prev. 2025;24:200340. doi:10.1016/j.ijcrp.2024.200340
- Li B, Hu M, Ma Y, Sun X, Wu D, et al. Association between Vitamin E, Vitamin B6, and Vitamin B12 with coronary heart disease. Sci Rep. 2024;14:19960. doi:10.1038/s41598-024-68413-8
- Zhang F, Zhang Y, Qian S, Qian X, Jiao J, et al. Injectable and Conductive Nanomicelle Hydrogel with α-Tocopherol Encapsulation for Enhanced Myocardial Infarction Repair. ACS Nano. 2024;18:10216. doi:10.1021/acsnano.4c00509
- Rivas-Garcia L, Quintana-Navarro GM, Torres-Peña JD, Arenas-de Larriva AP, Alcala-Díaz JF, et al. Dietary antioxidant intake reduces carotid intima-media thickness in coronary heart disease patients: From the CORDIOPREV study. Free Radic Biol Med. 2024;210:221. doi:10.1016/j.freeradbiomed.2023.11.026
- Mehvari F, Imanparast F, Mohaghegh P, Alimoradian A, Khansari N, et al. Protective effects of paraoxonase-1, vitamin E and selenium, and oxidative stress index on the susceptibility of low density lipoprotein to oxidation in diabetic patients with/without coronary artery disease. Eur J Med Res. 2023;28:300. doi:10.1186/s40001-023-01254-9
- Moustafa I, Connolly C, Anis M, Mustafa H, Oosthuizen F, et al. A prospective study to evaluate the efficacy and safety of vitamin E and levocarnitine prophylaxis against doxorubicin-induced cardiotoxicity in adult breast cancer patients. J Oncol Pharm Pract. 2024;30:354. doi:10.1177/10781552231171114
- Reno-Bernstein CM, Oxspring M, Bayles J, Huang EY, Holiday I, et al. Vitamin E treatment in insulin-deficient diabetic rats reduces cardiac arrhythmias and mortality during severe hypoglycemia. Am J Physiol Endocrinol Metab. 2022;323:E428. doi:10.1152/ajpendo.00188.2022
- Heydarnia E, Taghian F, Jalali Dehkordi K, Moghadasi M. Regular combined training and vitamins modulated the apoptosis process in diabetic rats: Bioinformatics analysis of heart failure's differential genes expression network correlated with anti-apoptotic process. J Food Biochem. 2022;46:e14291. doi:10.1111/jfbc.14291
- Ojo OO, Obaidu IM, Obigade OC, Olorunsogo OO. Quercetin and vitamin E ameliorate cardio-apoptotic risks in diabetic rats. Mol Cell Biochem. 2022;477:793. doi:10.1007/s11010-021-04332-w
- Abdelghffar EA, Obaid WA, Elgamal AM, Daoud R, Sobeh M, et al. Pea (Pisum sativum) peel extract attenuates DOX-induced oxidative myocardial injury. Biomed Pharmacother. 2021;143:112120. doi:10.1016/j.biopha.2021.112120
- Asiedu-Gyekye IJ, Arhin E, Arthur SA, N'guessan BB, Amponsah SK. Genotoxicity, nitric oxide level modulation and cardio-protective potential of Kalanchoe Integra Var. Crenata (Andr.) Cuf Leaves in murine models. J Ethnopharmacol. 2022;283:114640. doi:10.1016/j.jep.2021.114640
